Current pharmacokinetic–pharmacodynamic models describing the haemodynamic changes often do not include necessary feedback mechanisms. These models provide adequate description of current data but may fail to adequately extrapolate to additional… Click to show full abstract
Current pharmacokinetic–pharmacodynamic models describing the haemodynamic changes often do not include necessary feedback mechanisms. These models provide adequate description of current data but may fail to adequately extrapolate to additional scenarios. This study aims to develop a minimal model to describe the short‐term changes of haemodynamics that can be used as the basis for model development by future researchers.
               
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