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Effects of Hypericum perforatum (St John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans

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To investigate the influence of a cytochrome P450 CYP3A4 and efflux transporter P‐glycoprotein (P‐gp) inducing Hypericum perforatum extract on the pharmacokinetics and pharmacodynamics of rivaroxaban. Click to show full abstract

To investigate the influence of a cytochrome P450 CYP3A4 and efflux transporter P‐glycoprotein (P‐gp) inducing Hypericum perforatum extract on the pharmacokinetics and pharmacodynamics of rivaroxaban.

Keywords: pharmacodynamics rivaroxaban; effects hypericum; pharmacokinetics pharmacodynamics; hypericum perforatum; perforatum john

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020

Link to full text (if available)


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