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Current FDA‐approved label recommends that the dosage of polymyxin B should be adjusted according to renal function. However, the correlation between polymyxin B pharmacokinetics (PK) and creatinine clearance (CrCL) is… Click to show full abstract
Current FDA‐approved label recommends that the dosage of polymyxin B should be adjusted according to renal function. However, the correlation between polymyxin B pharmacokinetics (PK) and creatinine clearance (CrCL) is poor. This study aimed to develop a population PK model of polymyxin B in adult patients with various renal functions and to identify a dosing strategy.
Keywords:
various renal;
renal functions;
polymyxin;
patients various;
population;
adult patients
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020
Link to full text (if available)
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!