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SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial‐protective properties, while limiting S1P1 desensitization and consequent lymphocyte‐count reduction associated with higher doses.… Click to show full abstract
SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial‐protective properties, while limiting S1P1 desensitization and consequent lymphocyte‐count reduction associated with higher doses. The aim was to show whether S1P1 activation can promote endothelial effects in patients and, if so, select SAR247799 doses for further clinical investigation.
Keywords:
endothelial protective;
biased sphingosine;
sar247799;
sphingosine phosphate;
protein biased;
phosphate receptor
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020
Link to full text (if available)
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2020
Link to full text (if available)
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recommendations!