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MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients

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Develop a robust and user‐friendly software tool for the prediction of dopamine D2 receptor occupancy (RO) in patients with schizophrenia treated with either olanzapine or risperidone, in order to facilitate… Click to show full abstract

Develop a robust and user‐friendly software tool for the prediction of dopamine D2 receptor occupancy (RO) in patients with schizophrenia treated with either olanzapine or risperidone, in order to facilitate clinician exploration of the impact of treatment strategies on RO using sparse plasma concentration measurements.

Keywords: receptor occupancy; plasma; dopamine receptor

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2022

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