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Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations

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Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical… Click to show full abstract

Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical practice. Therefore, the current study aimed to evaluate the variations of meropenem dosing guidelines and compare the difference between guideline and clinical practice in terms of the probability of target attainment.

Keywords: optimal dose; practice; dose meropenem; neonatal sepsis; clinical practice

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2022

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