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Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and… Click to show full abstract
Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but the relationship of these changes to drug concentrations is not well characterized.
Keywords:
amodiaquine metabolite;
effect relationships;
metabolite desethylamodiaquine;
relationships amodiaquine;
cardiovascular concentration;
concentration effect
Journal Title: British journal of clinical pharmacology
Year Published: 2022
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Journal Title: British journal of clinical pharmacology
Year Published: 2022
Link to full text (if available)
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recommendations!