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A population pharmacokinetic (PPK) model was developed to characterize pharmacokinetics (PK) of subcutaneous or intravenous daratumumab administration in a new indication (i.e., combination with pomalidomide and dexamethasone [D‐Pd] in patients… Click to show full abstract
A population pharmacokinetic (PPK) model was developed to characterize pharmacokinetics (PK) of subcutaneous or intravenous daratumumab administration in a new indication (i.e., combination with pomalidomide and dexamethasone [D‐Pd] in patients with relapsed or refractory multiple myeloma [RRMM]). Analyses were conducted to explore exposure–response (E‐R) relationships for efficacy and select treatment‐emergent adverse events (TEAEs).
Keywords:
exposure response;
pomalidomide dexamethasone;
relapsed refractory;
refractory multiple;
population;
multiple myeloma
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2022
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2022
Link to full text (if available)
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recommendations!