LAUSR

BACKGROUND By 2030, over 50% of individuals living with bipolar disorder (BD) are expected to be aged ≥ 50 years. However, older age bipolar disorder (OABD) remains understudied. There are limited large-scale prospectively collected data organized in key dimensions capable of addressing several fundamental questions about BD affecting this subgroup of patients. METHODS We developed initial recommendations for the essential dimensions for OABD data collection, based on 1) a systematic review of measures used in OABD studies, 2) a Delphi consensus of international OABD experts, 3) experience with harmonizing OABD data in the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD, n≥4,500 participants), and 4) critical feedback from 34 global experts in geriatric mental health. RESULTS We identified 15 key dimensions and variables within each that are relevant for the investigation of OABD: 1) demographics, 2) core symptoms of depression and 3) mania, 4) cognition screening and subjective cognitive function, 5) elements for BD diagnosis, 6) descriptors of course of illness, 7) treatment, 8) suicidality , 9) current medication , 10) psychiatric comorbidity, 11) psychotic symptoms, 12) general medical comorbidities, 13) functioning , 14) family history, and 15) other. We also recommend particular instruments for capturing some of the dimensions and variables. CONCLUSION The essential data dimensions we present should be of use to guide future international data collection in OABD and clinical practice. In the longer-term, we aim to establish a prospective consortium using this core set of dimensions and associated variables to answer research questions relevant to OABD.