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Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen–antibody reaction time for detection

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Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the mucous membranes and the skin.1 PV produces autoantibodies targeting the desmosomal adhesion molecules desmoglein (Dsg)3 and Dsg1.2 To detect these… Click to show full abstract

Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the mucous membranes and the skin.1 PV produces autoantibodies targeting the desmosomal adhesion molecules desmoglein (Dsg)3 and Dsg1.2 To detect these autoantibodies, enzyme-linked immunosorbent assay (ELISA) has been widely used. Recently, chemiluminescent enzyme immunoassay (CLEIA) has been newly developed. This article is protected by copyright. All rights reserved.

Keywords: immunoassay require; chemiluminescent enzyme; undetectable chemiluminescent; autoantibodies undetectable; enzyme immunoassay

Journal Title: British Journal of Dermatology
Year Published: 2019

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