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Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts

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Linear morphoea (LM) is a rare connective tissue disorder characterized by a line of thickened skin and subcutaneous tissue and can also affect the underlying muscle and bone. Little is… Click to show full abstract

Linear morphoea (LM) is a rare connective tissue disorder characterized by a line of thickened skin and subcutaneous tissue and can also affect the underlying muscle and bone. Little is known about the disease aetiology, with treatment currently limited to immune suppression, and disease recurrence postā€treatment is common.

Keywords: differential expression; linear morphoea; expression secreted; factors sostdc1; secreted factors; sostdc1 adamts8

Journal Title: British Journal of Dermatology
Year Published: 2019

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