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Detection of cell‐free circulating BRAFV600E by droplet digital polymerase chain reaction in patients with and without melanoma under dermatological surveillance

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The p.V600E mutation in the BRAF protein is the most frequent mutation in cutaneous melanoma and is a recurrent alteration found in common benign naevi. Analysis of the cell‐free BRAF… Click to show full abstract

The p.V600E mutation in the BRAF protein is the most frequent mutation in cutaneous melanoma and is a recurrent alteration found in common benign naevi. Analysis of the cell‐free BRAF c.1799T>A, p.V600E mutation (cfBRAFV600E) in plasma has emerged as a biomarker for monitoring prognosis and treatment response in patients with melanoma.

Keywords: circulating brafv600e; cell; cell free; free circulating; brafv600e droplet; detection cell

Journal Title: British Journal of Dermatology
Year Published: 2019

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