LAUSR

The etiology of infantile haemangiomas is still not fully understood. The hypothesis of tissue hypoxia was corroborated by children presenting with large segmental facial haemangiomas (SFH) in association with ipsilateral cerebro- and/or cervicovascular anomalies (CVA). PHACE syndrome (posterior fossa malformations, haemangioma, arterial, cardiac, eye and/or sternal anomalies, OMIM 606519) can be diagnosed in about 31% of all children with large facial haemangiomas. Most children have only one extracutaneous manifestation1 . CVA were reported in up to 91% of all PHACE patients. Blood-flow limiting CVA confer a risk of arterial ischaemic stroke2 . CVA are thus the most prevalent and relevant extracutaneous manifestations of PHACE syndrome This article is protected by copyright. All rights reserved.