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Circulating concentrations of the split complement factor C5a are significantly increased in hidradenitis suppurativa (HS)1 . C5a exerts strong chemotaxis and activation of neutrophils at the inflammatory areas so that… Click to show full abstract
Circulating concentrations of the split complement factor C5a are significantly increased in hidradenitis suppurativa (HS)1 . C5a exerts strong chemotaxis and activation of neutrophils at the inflammatory areas so that blockade may be a promising therapeutic target. IFX-1 is a monoclonal IgG4 kappa antibody that selectively binds to C5a and blocks its biological activity (data on file at InflaRx).
Keywords:
c5a;
hidradenitis suppurativa;
efficacy complement;
clinical efficacy
Journal Title: British Journal of Dermatology
Year Published: 2020
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Journal Title: British Journal of Dermatology
Year Published: 2020
Link to full text (if available)
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recommendations!