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We read with interest the BJD online publication by Gambichler and colleagues1 about a decline of programmed death (PD)-1+ circulating T regulatory cells (Tregs) predicting clinical outcome in anti-PD-1 therapy.… Click to show full abstract
We read with interest the BJD online publication by Gambichler and colleagues1 about a decline of programmed death (PD)-1+ circulating T regulatory cells (Tregs) predicting clinical outcome in anti-PD-1 therapy. The study highlights the potential and importance of immune monitoring in anti-PD-1 checkpoint therapy in malignant melanoma. However, their conclusion about anti-PD-1 antibody treatment effecting a decline of PD-1+ Tregs is misleading.
Keywords:
death;
immune monitoring;
neutralizing antidrug;
competition neutralizing;
antidrug antibodies;
epitope competition
Journal Title: British Journal of Dermatology
Year Published: 2020
Link to full text (if available)
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Journal Title: British Journal of Dermatology
Year Published: 2020
Link to full text (if available)
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recommendations!