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Porokeratosis is an autosomal dominant skin disorder characterized by annular or circular skin lesions surrounded by a hyperkeratotic rim called "cornoid lamella".1 Clinical subtypes of porokeratosis have been classified mostly… Click to show full abstract
Porokeratosis is an autosomal dominant skin disorder characterized by annular or circular skin lesions surrounded by a hyperkeratotic rim called "cornoid lamella".1 Clinical subtypes of porokeratosis have been classified mostly based on age at onset, and the distribution and size of skin lesions.1 It has been demonstrated that most patients with porokeratosis have a heterozygous germline mutation in genes that encode enzymes of the mevalonate pathway, MVK, MVD, PMVK, or FDPS, in both familial and sporadic cases.
Journal Title: British Journal of Dermatology
Year Published: 2021
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