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Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is an autosomal dominant genetic blistering disease caused by a mutation in a calcium transporter protein in the Golgi apparatus… Click to show full abstract
Hailey-Hailey disease (HHD), also known as familial benign chronic pemphigus, is an autosomal dominant genetic blistering disease caused by a mutation in a calcium transporter protein in the Golgi apparatus encoded by the ATP2C1 gene on chromosome 3.1 Defective calcium homeostasis in the Golgi apparatus leads to loss of keratinocyte cell-cell adhesion leading to acantholysis.
Keywords:
disease treated;
treated dupilumab;
disease;
hailey disease;
hailey;
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Journal Title: British Journal of Dermatology
Year Published: 2021
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Journal Title: British Journal of Dermatology
Year Published: 2021
Link to full text (if available)
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recommendations!