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Lesional activation of Tc17 cells in Behçet disease and psoriasis supports HLA class I‐mediated autoimmune responses *

Behçet disease (BD) presents with lymphocytic and neutrophilic vasculitis of unknown aetiology. HLA‐B*51, the endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin 23 receptor (IL23R)/IL12R are genetic risk factors. IL‐23 regulates… Click to show full abstract

Behçet disease (BD) presents with lymphocytic and neutrophilic vasculitis of unknown aetiology. HLA‐B*51, the endoplasmic reticulum aminopeptidase 1 (ERAP1), and interleukin 23 receptor (IL23R)/IL12R are genetic risk factors. IL‐23 regulates IL‐17A, which controls the recruitment and activation of neutrophils.

Keywords: beh disease; tc17 cells; disease; lesional activation; activation tc17

Journal Title: British Journal of Dermatology
Year Published: 2021

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