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Interleukin‐33 antibody failed to demonstrate benefit in a phase II, double‐blind, randomized, placebo‐controlled study in adult patients with moderate‐to‐severe atopic dermatitis

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individuals. While this finding was not statistically significant, it may be of clinical significance. A delay in time to definitive surgery may contribute to the disproportionate morbidity observed in this… Click to show full abstract

individuals. While this finding was not statistically significant, it may be of clinical significance. A delay in time to definitive surgery may contribute to the disproportionate morbidity observed in this population. Our data demonstrate that pigmented variants were more common in Hispanic individuals, which is consistent with existing data. Hispanic individuals were twice as likely to present with BCCs in area H compared with NHW individuals. This finding is similar to that of Perper et al. in which keratinocyte carcinoma in Hispanic individuals were primarily located in area H. NMSC has a lower incidence in skin of colour and requires a high degree of clinical suspicion for accurate and timely diagnosis. Surveillance bias may explain the higher incidence of tumours observed in area H. Hispanic individuals may be more likely to seek dermatological care for more apparent lesions on the mask areas of the face and hands. Finally, our data reveal that Hispanic patients were significantly more likely to undergo flaps for reconstruction, while NHW individuals were more likely to undergo linear closures. To our knowledge this finding has not been previously reported. The finding in our study and studies by others, showing that Hispanic individuals are more likely to present with BCC in high-risk locations, may account for the higher incidence of flap closures we observed. Tissue rearrangement is often required in the high-risk mask areas of the face to preserve functional anatomy. We consider this finding a marker for high postoperative morbidity in Hispanic patients. Overall, our findings show that Hispanic individuals with BCC are more likely to be female and to present with pigmented variants in high-risk locations. Hispanic patients are more likely to undergo flaps following Mohs surgery for BCC. Limitations of this study include the retrospective nature and small sample size. Still, our findings are an important addition to the growing body of literature on NMSC in Hispanic individuals.

Keywords: likely undergo; hispanic patients; high risk; interleukin antibody; hispanic individuals; study

Journal Title: British Journal of Dermatology
Year Published: 2022

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