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Mucosal haemangioma in the setting of treatment with trastuzumab emtansine (T‐DM1)

D EAR E DITOR , A 46-year-old woman with invasive lobular carci-noma of the breast presented to the oncodermatology clinic for a growth on the ventral tongue that developed approxi-mately… Click to show full abstract

D EAR E DITOR , A 46-year-old woman with invasive lobular carci-noma of the breast presented to the oncodermatology clinic for a growth on the ventral tongue that developed approxi-mately 6 months after initiation of trastuzumab emtansine (T-DM1). Prior oncological treatment included bilateral mastec-tomy with axillary lymph node dissection, radiation therapy and TCHP chemotherapy. An excisional biopsy was performed both to rule out malignancy and for patient comfort; pathol-ogy was consistent with lobular capillary angioma in the setting of T-DM1. The formation of mucocutaneous telangiec-tasias following T-DM1 has been reported, the mechanism of which is believed to be endothelial cell microtubule disrup-tion. 1 Of note, this patient did not have additional risk factors for haemangioma development. Due to the benign nature of the lesion, no further treatment was pursued.

Keywords: trastuzumab emtansine; emtansine dm1; mucosal haemangioma; treatment; dm1

Journal Title: British Journal of Dermatology
Year Published: 2022

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