D EAR E DITOR , A 46-year-old woman with invasive lobular carci-noma of the breast presented to the oncodermatology clinic for a growth on the ventral tongue that developed approxi-mately… Click to show full abstract
D EAR E DITOR , A 46-year-old woman with invasive lobular carci-noma of the breast presented to the oncodermatology clinic for a growth on the ventral tongue that developed approxi-mately 6 months after initiation of trastuzumab emtansine (T-DM1). Prior oncological treatment included bilateral mastec-tomy with axillary lymph node dissection, radiation therapy and TCHP chemotherapy. An excisional biopsy was performed both to rule out malignancy and for patient comfort; pathol-ogy was consistent with lobular capillary angioma in the setting of T-DM1. The formation of mucocutaneous telangiec-tasias following T-DM1 has been reported, the mechanism of which is believed to be endothelial cell microtubule disrup-tion. 1 Of note, this patient did not have additional risk factors for haemangioma development. Due to the benign nature of the lesion, no further treatment was pursued.
               
Click one of the above tabs to view related content.