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Secukinumab for the treatment of adult‐onset pityriasis rubra pilaris: a single‐arm clinical trial with transcriptomic analysis *

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The pathogenesis of pityriasis rubra pilaris (PRP) is not completely understood, but interleukin (IL)‐17 has been shown to play a critical role. There are no reliable immunomodulatory agents to treat… Click to show full abstract

The pathogenesis of pityriasis rubra pilaris (PRP) is not completely understood, but interleukin (IL)‐17 has been shown to play a critical role. There are no reliable immunomodulatory agents to treat PRP. We conducted an open‐label, single‐arm clinical trial of secukinumab, a monoclonal antibody that inhibits IL‐17A, for the treatment of PRP.

Keywords: rubra pilaris; arm clinical; single arm; clinical trial; pityriasis rubra

Journal Title: British Journal of Dermatology
Year Published: 2022

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