LAUSR

recurrent mutations in chronic lymphocytic leukaemia. Nature, 475, 101–105. Treon, S.P., Xu, L., Yang, G., Zhou, Y., Liu, X., Cao, Y., Sheehy, P., Manning, R.J., Patterson, C.J., Tripsas, C., Arcaini, L., Pinkus, G.S., Rodig, S.J., Sohani, A.R., Harris, N.L., Laramie, J.M., Skifter, D.A., Lincoln, S.E. & Hunter, Z.R. (2012) MYD88 L265P somatic mutation in Waldenstrom’s macroglobulinemia. The New England Journal of Medicine, 367, 826–833. Varettoni, M., Arcaini, L., Zibellini, S., Boveri, E., Rattotti, S., Riboni, R., Corso, A., Orlandi, E., Bonfichi, M., Gotti, M., Pascutto, C., Mangiacavalli, S., Croci, G., Fiaccadori, V., Morello, L., Guerrera, M.L., Paulli, M. & Cazzola, M. (2013) Prevalence and clinical significance of the MYD88 L265P somatic mutation in Waldenstrom macroglobulinemia, and related lymphoid neoplasms. Blood, 121, 2522–2528. Walensky, L.D. & Bird, G.H. (2014) Hydrocarbonstapled peptides: principles, practice, and progress. Journal of Medicinal Chemistry, 57, 6275–6288. Xu, L., Hunter, Z.R., Yang, G., Zhou, Y., Cao, Y., Liu, X., Morra, E., Trojani, A., Greco, A., Arcaini, L., Varettoni, M., Brown, J.R., Tai, Y.T., Anderson, K.C., Munshi, N.C., Patterson, C.J., Manning, R.J., Tripsas, C.K., Lindeman, N.I. & Treon, S.P. (2013) MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood, 121, 2051–2058. Yang, G., Zhou, Y., Liu, X., Xu, L., Cao, Y., Manning, R.J., Patterson, C.J., Buhrlage, S.J., Gray, N., Tai, Y.T., Anderson, K.C., Hunter, Z.R. & Treon, S.P. (2013) A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenstrom macroglobulinemia. Blood, 122, 1222–1232. Yang, G., Liu, X., Chen, J., Xu, L., Tsakmaklis, N., Chen, J., Patterson, C.J., Castillo, J.J., Cohen, P., Tan, L., Buhrlage, S., Gray, N. & Treon, S.P. (2015). Targeting IRAK1/IRAK4 signaling in Waldenstrom’s Macroglobulinemia. Blood, 126, 4004. Abstract 4004.