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Hypomegakaryocytic thrombocytopenia and increased number of PNH‐phenotype cells – an emerging subgroup of myelodysplastic syndrome showing frequent response to immunosuppression – RESPONSE to Rafferty & Leach

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Fozza, C., Contini, S., Galleu, A., Simula, M.P., Virdis, P., Bonfigli, S. & Longinotti, M. (2009) Patients with Myelodysplastic Syndromes display several T-cell expansions, which are mostly polyclonal in the… Click to show full abstract

Fozza, C., Contini, S., Galleu, A., Simula, M.P., Virdis, P., Bonfigli, S. & Longinotti, M. (2009) Patients with Myelodysplastic Syndromes display several T-cell expansions, which are mostly polyclonal in the CD4(+) subset and oligoclonal in the CD8(+) subset. Experimental Haematology, 37, 947–955. Iwanaga, M., Furukawa, K., Amenomori, T., Mori, H., Nakamura, H., Fuchigami, K., Kamihira, S., Nakakuma, H. & Tomonaha, M. (1998) Paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes. British Journal of Haematology, 102, 465–474. Killick, S.B., Carter, C., Culligan, D., Das-Gupta, E., Drummond, M., Enright, H., Jones, G.L., Kell, J., Mills, J., Mufti, G., Parker, J., Raj, K., Sternberg, A., Was, P. & Bowen, D.; British Committee for Standards in Haematology. (2013) Guidelines for the diagnosis and management of adult myelodysplastic syndromes. British Journal of Haematology, 164, 503–525. Kordasti, S.Y., Afzali, B., Lim, Z., Ingram, W., Hayden, J., Barber, L., Matthew, K., Chelliah, R., Guinn, B., Lombardi, G., Farzaneh, F. & Mufti, G.J. (2009) IL-17-producing CD4(+) T cells, pro-inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome. British Journal of Haematology, 145, 64–72. Okamoto, T., Okada, M., Yamada, S., Takatsuka, H., Wada, H., Tamura, A., Fujimora, Y., Takemoto, Y. & Kakishita, E. (2000) Good response to cyclosporine therapy in patients with myelodysplastic syndromes having the HLADRB1*1501 allele. Leukemia, 14, 44–346. Saito, C., Ishiyama, K., Yamazaki, H., Zaimoku, Y. & Nakao, S. (2016) Hypomegakaryocytic thrombocytopenia (HMT): an immune-mediated bone marrow failure characterized by an increased number of PNH-phenotype cells and high plasma thrombopoietin levels. British Journal of Haematology, 175, 246–251. Wang, H., Chuhjo, T., Yasue, S., Omine, M. & Nakao, S. (2002) Clinical significance of a minor population of paroxysmal nocturnal haemoglobinuria-type cells in bone marrow failure syndrome. Blood, 100, 897–902. Wang, S.A., Pozdnyakova, O., Jorgensen, J.L., Medeiros, L.J., Stachurski, D., Anderson, M., Raza, A. & Woda, B.A. (2009) Detection of paroxysmal nocturnal haemoglobinuria clones in patients with myelodysplastic syndromes and related bone marrow diseases. Haematologica, 94, 29–37.

Keywords: myelodysplastic syndromes; response; patients myelodysplastic; haematology; british journal; journal haematology

Journal Title: British Journal of Haematology
Year Published: 2018

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