LAUSR

genetic subtype. Fig S1. (A) Bacterial artificial chromosome (BACs) used for fluorescence in situ hybridization DUSP22 break-apart assays with hg 19 co-ordinates. (B) Partial karyotype showing the expected site of chromosomal localization (6p25.3) on normal metaphases. (C) Schematic diagram indicating the alignment of in house BAC probes to the DUSP22 locus of UCSC Hg19. (D) A representative example of interphases with DUSP22 break-apart in an ALCL case demonstrating a rearrangement, with 1 normal fusion and separation of the red and green signal (arrows). Fig S2. (A) Bacterial Artificial Chromosomes (BACs) used for fluorescence in situ hybridization break-apart assays detect TP63 rearrangements with hg 19 coordinates. (B) Partial karyotype showing the expected site of chromosomal localization (3q28) on normal metaphases. (C) Schematic diagram indicating the alignment of in house BAC probes to the TP63 locus of UCSC Hg19. (D) Sole case of TP63 breakapart rearrangement, with 1 normal fusion and separation of the red and green signal (arrows) indicating a rearrangement. Fig S3. (A) Progression-free survival ALK-positive (pos) versus ALK-negative (neg) ALCL. (B) Overall survival of ALK-positive versus ALK-negative. Fig S4. (A) Progression free survival in triple negative ALK-negative (neg) ALCL by CD3 expression. (B) Overall survival in triple negative ALK-negative (neg) ALCL by CD3 expression.