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Morphological characterization of acute myeloid leukaemia with t(11;17)(q23;q21)/ZBTB16::RARA fusion

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(haemo-globin (plate-lets × 9 Microscopic examination of the blood abnormal promyelocytes with regular nuclei, par-tially chromatin and cytoplasm packed with large granules (left images, all images May- Grünwald-Giemsa, ×100 objective).… Click to show full abstract

(haemo-globin (plate-lets × 9 Microscopic examination of the blood abnormal promyelocytes with regular nuclei, par-tially chromatin and cytoplasm packed with large granules (left images, all images May- Grünwald-Giemsa, ×100 objective). No Auer rods were observed. leukaemic cells in a marrow aspirate The were suggestive of promyelocytic leukaemia the absence of “faggot” cells. marked dysgranulopoiesis, marked hypogranularity, abnormal nuclear segmentation and pseudo- Pelger- Huët forms, was present (right images). Immunophenotyping strong of myeloperoxidase no HLA- banded analysis ::

Keywords: leukaemia; leukaemia q23; characterization acute; morphological characterization; acute myeloid; myeloid leukaemia

Journal Title: British Journal of Haematology
Year Published: 2022

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