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Additive effects of the Rho kinase inhibitor Y‐27632 and vardenafil on relaxation of the corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure

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To evaluate the expression of the Rho/Rho‐associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to… Click to show full abstract

To evaluate the expression of the Rho/Rho‐associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to test the functional effects of two Rho kinase inhibitors (RKIs) on erectile tissue of patients with severe ED, which did not respond to phosphodiesterase type 5 inhibitors (PDE5Is).

Keywords: corpus cavernosum; rho kinase; inhibitor; erectile dysfunction

Journal Title: BJU International
Year Published: 2017

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