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Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. The cytokine TNF‐α induces vascular dysfunction… Click to show full abstract
Obesity is associated with structural and functional changes in perivascular adipose tissue (PVAT), favouring release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. The cytokine TNF‐α induces vascular dysfunction and is produced by PVAT. We tested the hypothesis that obesity‐associated PVAT dysfunction was mediated by augmented mitochondrial ROS (mROS) generation due to increased TNF‐α production in this tissue.
Keywords:
mitochondrial ros;
perivascular adipose;
tissue;
generation;
adipose tissue
Journal Title: British Journal of Pharmacology
Year Published: 2017
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Journal Title: British Journal of Pharmacology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!