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Restoration of perivascular adipose tissue function in diet‐induced obese mice without changing bodyweight

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We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity‐induced vascular dysfunction in mice. The current… Click to show full abstract

We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity‐induced vascular dysfunction in mice. The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity.

Keywords: tissue function; perivascular adipose; restoration perivascular; adipose tissue

Journal Title: British Journal of Pharmacology
Year Published: 2017

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