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Role of inducible nitric oxide synthase in endothelium‐independent relaxation to raloxifene in rat aorta

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Raloxifene can induce both endothelium‐dependent and ‐independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium‐independent relaxation are still incompletely understood. The purpose of present study… Click to show full abstract

Raloxifene can induce both endothelium‐dependent and ‐independent relaxation in different arteries. However, the underlying mechanisms by which raloxifene triggers endothelium‐independent relaxation are still incompletely understood. The purpose of present study was to examine the roles of NOSs and Ca2+ channels in the relaxant response to raloxifene in the rat isolated, endothelium‐denuded aorta.

Keywords: raloxifene rat; independent relaxation; endothelium independent; raloxifene

Journal Title: British Journal of Pharmacology
Year Published: 2017

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