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Identification and pharmacological characterization of succinate receptor agonists

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The succinate receptor (formerly GPR91 or SUCNR1) is described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of succinate… Click to show full abstract

The succinate receptor (formerly GPR91 or SUCNR1) is described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of succinate receptors has remained ill‐defined because no pharmacological tools were available. We report on the discovery of the first family of potent synthetic agonists.

Keywords: pharmacological characterization; succinate receptor; identification pharmacological; succinate; characterization succinate

Journal Title: British Journal of Pharmacology
Year Published: 2017

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