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Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls… Click to show full abstract
Abnormal glycolytic metabolism contributes to joint inflammation in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase 3 (PFKFB3), a bifunctional enzyme that controls the glycolytic rate, in regulating fibroblast‐like synoviocyte (FLS)‐mediated synovial inflammation and invasiveness in RA.
Keywords:
fibroblast like;
synovial inflammation;
inflammation;
phosphofructo kinase;
mediated synovial;
rheumatoid arthritis
Journal Title: British Journal of Pharmacology
Year Published: 2017
Link to full text (if available)
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Journal Title: British Journal of Pharmacology
Year Published: 2017
Link to full text (if available)
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recommendations!