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Chromosomal instability is not only a hallmark of cancer but also an attractive therapeutic target. A diverse set of mitotic kinases maintains chromosomal stability. One of these is monopolar spindle… Click to show full abstract
Chromosomal instability is not only a hallmark of cancer but also an attractive therapeutic target. A diverse set of mitotic kinases maintains chromosomal stability. One of these is monopolar spindle 1 (Mps1, also known as TTK), which is essential for chromosome alignment and for the spindle assembly checkpoint (SAC). Pharmacological inhibition of Mps1 has been suggested as a cancer therapeutic; however, despite the existence of a novel Mps1 inhibitor, TC Mps1 12, no such studies have been performed.
Keywords:
mps1;
chromosomal instability;
mps1 inhibitor;
novel mps1
Journal Title: British Journal of Pharmacology
Year Published: 2017
Link to full text (if available)
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Journal Title: British Journal of Pharmacology
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!