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Endocannabinoids play an important role in modulating spinal nociceptive signalling, crucial for the development of pain. The cannabinoid CB1 receptor and the TRPV1 cation channel are both activated by the… Click to show full abstract
Endocannabinoids play an important role in modulating spinal nociceptive signalling, crucial for the development of pain. The cannabinoid CB1 receptor and the TRPV1 cation channel are both activated by the endocannabinoid anandamide, a product of biosynthesis from the endogenous lipid precursor N‐arachidonoylphosphatidylethanolamine (20:4‐NAPE). Here, we report CB1 receptor‐ and TRPV1‐mediated effects of 20:4‐NAPE on spinal synaptic transmission in control and inflammatory conditions.
Keywords:
transmission;
affects modulation;
inflammation affects;
peripheral inflammation;
synaptic transmission;
modulation nociceptive
Journal Title: British Journal of Pharmacology
Year Published: 2018
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Journal Title: British Journal of Pharmacology
Year Published: 2018
Link to full text (if available)
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recommendations!