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The anti‐migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel

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The mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to… Click to show full abstract

The mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine.

Keywords: isopetasin desensitizes; butterbur extracts; extracts isopetasin; anti migraine; component butterbur; migraine component

Journal Title: British Journal of Pharmacology
Year Published: 2017

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