Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been… Click to show full abstract
Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been extensively investigated, the bioactivity of Δ9‐tetahydrocannabinol acid (Δ9‐THCA) is largely unknown, despite its occurrence in different Cannabis preparations. Here we have assessed possible neuroprotective actions of Δ9‐THCA through modulation of PPARγ pathways.
               
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