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Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

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Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been… Click to show full abstract

Phytocannabinoids are produced in Cannabis sativa L. in acidic form and are decarboxylated upon heating, processing and storage. While the biological effects of decarboxylated cannabinoids such as Δ9‐tetrahydrocannabinol have been extensively investigated, the bioactivity of Δ9‐tetahydrocannabinol acid (Δ9‐THCA) is largely unknown, despite its occurrence in different Cannabis preparations. Here we have assessed possible neuroprotective actions of Δ9‐THCA through modulation of PPARγ pathways.

Keywords: acid potent; agonist neuroprotective; potent ppar; ppar agonist; neuroprotective activity; tetrahydrocannabinolic acid

Journal Title: British Journal of Pharmacology
Year Published: 2017

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