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Adiponectin, an adipokine possessing profound insulin‐sensitizing and anti‐inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms,… Click to show full abstract
Adiponectin, an adipokine possessing profound insulin‐sensitizing and anti‐inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum protein 44 (ERp44). Obesity‐induced ER stress decreases the HMW form in serum, contributing to the development of insulin resistance and Type 2 diabetes. In this study, a panel of synthetic peptides, designed to target ERp44–adiponectin interactions, were tested for their effects on circulating levels of HMW adiponectin.
Journal Title: British Journal of Pharmacology
Year Published: 2017
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