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Up‐regulation of PYK2/PKCα‐dependent haem oxygenase‐1 by CO‐releasing molecule‐2 attenuates TNF‐α‐induced lung inflammation

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Haem oxygenase‐1 (HO‐1) could provide cytoprotection against various inflammatory diseases. However, the mechanisms underlying the protective effect of CO‐releasing molecule‐2 (CORM‐2)‐induced HO‐1 expression against TNF‐α‐induced inflammatory responses in human pulmonary… Click to show full abstract

Haem oxygenase‐1 (HO‐1) could provide cytoprotection against various inflammatory diseases. However, the mechanisms underlying the protective effect of CO‐releasing molecule‐2 (CORM‐2)‐induced HO‐1 expression against TNF‐α‐induced inflammatory responses in human pulmonary alveolar epithelial cells (HPAEpiCs) remain unknown.

Keywords: tnf induced; haem oxygenase; releasing molecule

Journal Title: British Journal of Pharmacology
Year Published: 2018

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