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Differential involvement of ipsilateral and contralateral spinal cord astrocyte D‐serine in carrageenan‐induced mirror‐image pain: role of σ1 receptors and astrocyte gap junctions

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Although we have recently demonstrated that spinal astrocyte gap junctions mediate the development of mirror‐image pain (MIP), it is still unclear which astrocyte‐derived factor is responsible for the development of… Click to show full abstract

Although we have recently demonstrated that spinal astrocyte gap junctions mediate the development of mirror‐image pain (MIP), it is still unclear which astrocyte‐derived factor is responsible for the development of MIP and how its production is controlled. In the present study, we focused on the role of ipsilateral versus contralateral D‐serine in the development of MIP and investigated the possible involvement of σ1 receptors and gap junctions in astrocyte D‐serine production.

Keywords: gap junctions; astrocyte; astrocyte serine; mirror image; image pain; astrocyte gap

Journal Title: British Journal of Pharmacology
Year Published: 2018

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