Gastrointestinal side effects of chemotherapy are an under‐recognized clinical problem, leading to dose reduction, delays and cessation of treatment, presenting a constant challenge for efficient and tolerated anti‐cancer treatment. We… Click to show full abstract
Gastrointestinal side effects of chemotherapy are an under‐recognized clinical problem, leading to dose reduction, delays and cessation of treatment, presenting a constant challenge for efficient and tolerated anti‐cancer treatment. We have found that oxaliplatin treatment results in intestinal dysfunction, oxidative stress and loss of enteric neurons. BGP‐15 is a novel cytoprotective compound with potential HSP72 co‐inducing and PARP inhibiting properties. In this study, we investigated the potential of BGP‐15 to alleviate oxaliplatin‐induced enteric neuropathy and intestinal dysfunction.
Journal Title: British Journal of Pharmacology
Year Published: 2018
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