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Apolipoprotein E favours the blunting by high‐fat diet of prostacyclin receptor activation in the mouse aorta

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NO‐mediated, endothelium‐dependent relaxations of isolated arteries are blunted by ageing and high‐fat diets, as well as by apolipoprotein E deletion. The present study was designed to test the hypothesis that… Click to show full abstract

NO‐mediated, endothelium‐dependent relaxations of isolated arteries are blunted by ageing and high‐fat diets, as well as by apolipoprotein E deletion. The present study was designed to test the hypothesis that apolipoprotein E deletion impairs endothelium‐dependent responses to prostacyclin (IP) receptor activation.

Keywords: receptor activation; prostacyclin receptor; high fat; apolipoprotein

Journal Title: British Journal of Pharmacology
Year Published: 2018

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