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Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis

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The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid‐like compounds seen can be attributed to the cannabinoid 1… Click to show full abstract

The cannabinoid system exerts functional regulation of neural stem cell (NSC) proliferation and adult neurogenesis, yet not all effects of cannabinoid‐like compounds seen can be attributed to the cannabinoid 1 (CB1) or CB2 receptor. The recently de‐orphaned GPR55 has been shown to be activated by numerous cannabinoid ligands suggesting that GPR55 is a third cannabinoid receptor. Here, we examined the role of GPR55 activation in NSC proliferation and early adult neurogenesis.

Keywords: stem cell; early adult; neural stem; proliferation

Journal Title: British Journal of Pharmacology
Year Published: 2018

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