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Glucocorticoids are a major class of stress hormones known to participate in stress‐induced hyperalgesia. Although 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1) is a key enzyme in the intracellular regeneration of glucocorticoids in… Click to show full abstract
Glucocorticoids are a major class of stress hormones known to participate in stress‐induced hyperalgesia. Although 11β‐hydroxysteroid dehydrogenase 1 (11β‐HSD1) is a key enzyme in the intracellular regeneration of glucocorticoids in the CNS, its role in pain perception has not been assessed. Here, we examined the effects of ASP3662, a novel 11β‐HSD1 inhibitor, on neuropathic and dysfunctional pain.
Keywords:
effects asp3662;
dysfunctional pain;
neuropathic dysfunctional;
asp3662 novel;
hydroxysteroid dehydrogenase;
pain
Journal Title: British Journal of Pharmacology
Year Published: 2018
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Journal Title: British Journal of Pharmacology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!