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Retinal and circulating miRNA expression patterns in diabetic retinopathy: An in silico and in vivo approach

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Diabetic retinopathy, a secondary complication of diabetes mellitus, can lead to irreversible vision loss. Currently, no treatment is approved for early phases of diabetic retinopathy. Modifications of the expression pattern… Click to show full abstract

Diabetic retinopathy, a secondary complication of diabetes mellitus, can lead to irreversible vision loss. Currently, no treatment is approved for early phases of diabetic retinopathy. Modifications of the expression pattern of miRNAs could be involved in the early retinal damage of diabetic subjects. Therefore, we aimed at identification of dysregulated miRNAs–mRNA interactions that might be biomarkers and pharmacological targets for diagnosis and treatment of early diabetic retinopathy.

Keywords: retinopathy; diabetic retinopathy; circulating mirna; retinal circulating; mirna expression

Journal Title: British Journal of Pharmacology
Year Published: 2019

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