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Endothelium‐derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases, an overproduction of endothelium‐derived prostacyclin (PGI2) can cause contraction rather than relaxation. Relaxin is well known for… Click to show full abstract
Endothelium‐derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases, an overproduction of endothelium‐derived prostacyclin (PGI2) can cause contraction rather than relaxation. Relaxin is well known for its vasoprotective actions, but the possibility that this peptide could also reverse endothelium‐derived vasoconstriction has never been investigated. We tested the hypothesis that short‐term relaxin treatment mitigates endothelium‐derived vasoconstriction in spontaneously hypertensive rats (SHR).
Journal Title: British Journal of Pharmacology
Year Published: 2019
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