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Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+/NADH ratios

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Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to… Click to show full abstract

Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional nicotinoyl hydrazones to target several pathological characteristics of AD.

Keywords: iron chelators; chelators aroyl; novel multifunctional; aroyl nicotinoyl; multifunctional iron; nicotinoyl hydrazone

Journal Title: British Journal of Pharmacology
Year Published: 2020

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