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Biased agonism describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor. Signalling is affected by rapid agonist‐induced receptor internalisation. Hence, the conventional… Click to show full abstract
Biased agonism describes the ability of ligands to differentially regulate multiple signalling pathways when coupled to a single receptor. Signalling is affected by rapid agonist‐induced receptor internalisation. Hence, the conventional use of equilibrium models may not be optimal, because (i) receptor numbers vary with time and, in addition, (ii) some pathways may show non‐monotonic profiles over time.
Keywords:
receptor signalling;
evaluation profiles;
profiles cb1;
cb1 cannabinoid;
cannabinoid receptor;
receptor
Journal Title: British Journal of Pharmacology
Year Published: 2020
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Journal Title: British Journal of Pharmacology
Year Published: 2020
Link to full text (if available)
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recommendations!