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Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina or ischaemic heart disease. These compounds are prodrugs… Click to show full abstract
Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina or ischaemic heart disease. These compounds are prodrugs which release their nitrovasodilators upon enzymic bioactivation by aldehyde dehydrogenase (ALDH2) or cytochromes P450 (CYP). Whereas ALDH2 is known to directly activate organic nitrates in vessels, the contribution of vascular CYPs is unknown and was studied here.
Keywords:
vascular biotransformation;
nitrates independent;
independent cytochrome;
cytochrome p450;
biotransformation organic;
organic nitrates
Journal Title: British Journal of Pharmacology
Year Published: 2021
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Journal Title: British Journal of Pharmacology
Year Published: 2021
Link to full text (if available)
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recommendations!