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l‐DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5‐HT1A receptors. Since the internal segment of the globus pallidus, homologous to… Click to show full abstract
l‐DOPA prolonged treatment leads to disabling motor complications as dyskinesia that could be decreased by drugs acting on 5‐HT1A receptors. Since the internal segment of the globus pallidus, homologous to the entopeduncular nucleus in rodents, seems to be involved in the etiopathology of l‐DOPA‐induced dyskinesia, we investigated whether the entopeduncular nucleus is modulated by the 5‐HT1A receptor partial and full agonists, buspirone, and 8‐hydroxy‐2‐(di‐n‐propylamino)‐tetralin (8‐OH‐DPAT) in control and 6‐hydroxydopamine (6‐OHDA)‐lesioned rats with or without long‐term l‐DOPA treatment.
Journal Title: British Journal of Pharmacology
Year Published: 2021
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