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Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In this study, we used a novel inhibitor of TRPV5 cation channels ‐… Click to show full abstract
Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In this study, we used a novel inhibitor of TRPV5 cation channels ‐ oxoglaucine to attenuate progression of deterioration and pathological changes in OA patient‐derived chondrocytes and OA animal model, by activating autophagy.
Keywords:
oxoglaucine mediates;
osteoarthritis;
mediates ca2;
trpv5;
ca2 influx;
influx activates
Journal Title: British Journal of Pharmacology
Year Published: 2021
Link to full text (if available)
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Journal Title: British Journal of Pharmacology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!