LAUSR

The endocannabinoids (eCBs) 2-arachidonoylglycerol and anandamide are among the best studied lipid messengers in the brain. By activating cannabinoid receptors in the central nervous system (CNS), eCBs tune synaptic function thereby influencing a variety of physiological and behavioral processes. Extensive research conducted over the last few decades has considerably enhanced our understanding of the molecular mechanisms and physiological functions of the eCB system. It is now well-established that eCBs are synthesized by postsynaptic neurons and serve as retrograde messengers that suppress neurotransmitter release at central synapses. While the detailed mechanisms by which eCBs gate synaptic function and behavioral processes are relatively well characterized, the mechanisms governing eCB transport at central synapses remain ill defined. Recently, several studies have begun to unravel the mechanisms governing intracellular and intercellular eCB transport. In this Review, we will focus on new advances in the mechanisms of intracellular and synaptic eCB transport in the CNS.